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Jacksonville Cruise Guide > Cruise Destinations > Golden Isles & Historic South

Historic South Cruises from Jacksonville

American Cruise Line offers one-way small ship cruises from Jacksonville/Amelia Island to Charleston, South Carolina. The 7-night trips are on the calm Intracoastal Waterway and stop at Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head Island (South Carolina) and Beaufort (South Carolina) before arriving in Charleston.

St Simons is the largest of the Golden Isles, the barrier islands along the coast of Georgia. Jekyll Island has the Georgia Sea Turtle Center and the lavish "Millionaire's Village" historic district.

Savannah is famous for its beautiful squares and historic style. It's extremely walkable, or you can take a trolley tour. The waterfront is loaded with fun restaurants and shops.

Hilton Head is a well-known oceanfront resort. Hit the beach, play golf (33 courses), sample the local food (250 restaurants), rent a bike (60 miles of trails), take an Antebellum home tour, or take a boat tour of the Sea Pines Forest Preserve.

Beaufort is a town that attracts many visitors. Explore the historic district on foot or in a horse-drawn carriage. Tour the surrounding Low Country region.

Your cruise ends in Charleston, which was rated #1 city in the USA by Travel + Leisure and Conde Nast Traveler magazine readers. Attractions include a huge historic district, excellent shopping, Fort Sumter, Magnolia Plantation and Middleton Place plantation.

Schedule of Departures

American Cruise Line Southeast Sea Islands cruises to Charleston, SC.
• 2025 departures: February 1, February 15, March 1, March 10, March 15, March 22, March 24, March 29, April 5, April 7, April 12, April 19, April 21, April 26, May 5, May 10, November 14, November 29, December 5, December 13, December 27.
• 2026 departures: January 30, February 6, February 13, February 20, February 27, March 6, March 13, March 18, March 20, March 27, April 1, April 3, April 10, April 15, April 24, April 29, May 8, November 9, November 17, November 23, December 1, December 7, December 15, December 21, December 29.

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