The small ships of American Cruise Lines are ready to give you a unique experience out of the Jacksonville, Florida. The modern 100-passenger ships are small enough to travel calm inland waterways and dock at quaint ports.
Amenities on American Cruise Line include guest lecturers, musical entertainment, good food, complimentary cocktails, resort casual dress, comfortable lounges and large observation decks. Many of the spacious staterooms have private balconies.
7-night Historic South and Golden Isles cruises to Charleston, South Carolina. Sail through the South on the calm Intracoastal Waterway. Ports of call include Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head Island (South Carolina) and Beaufort (South Carolina).
• 2025 departures: February 1, February 15, March 1, March 10, March 15, March 22, March 24, March 29, April 5, April 7, April 12, April 19, April 21, April 26, May 5, May 10, November 14, November 29, December 5, December 13, December 27.
7-night Great Rivers of Florida cruises. Round-trip from Jacksonville to Green Cove Springs (Florida), Palatka (Florida), Amelia Island (Florida), Tolomato River and St Augustine (Florida).
• 2025 departures: February 3, February 10, February 17, February 24, March 3, March 26, November 21, November 28, December 20, December 27.
14-night East Coast Inland Passage cruises from Amelia Island (Florida) to Washington (DC). Visit Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head (South Carolina), Beaufort (South Carolina), Charleston (South Carolina), Wilmington (North Carolina), Morehead City (North Carolina), Kitty Hawk (North Carolina), Norfolk (Virginia) and St Michaels (Maryland).
• 2025 departures: March 1, April 2, May 19, May 24.
14-night Grand Florida Coast & Keys cruises from Amelia Island (Florida) to St Petersburg (Florida). Visit St Augustine (Florida), Port Canaveral (Florida), West Palm Beach (Florida), Key Biscayne (Florida), Key West (Florida), Marco Island (Florida) and Punta Gorda (Florida).
• 2025 departures: November 1, November 10.
7-night Southeast Sea Islands cruises to Charleston, South Carolina. Sail through the South on the calm Intracoastal Waterway. Ports of call include Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head Island (South Carolina) and Beaufort (South Carolina).
• 2026 departures: January 30, February 6, February 13, February 20, February 27, March 6, March 13, March 18, March 20, March 27, April 1, April 3, April 10, April 15, April 24, April 29, May 8, November 9, November 17, November 23, December 1, December 7, December 15, December 21, December 29.
7-night Great Rivers of Florida cruises. Round-trip from Jacksonville to Green Cove Springs (Florida), Palatka (Florida), Amelia Island (Florida), Tolomato River and St Augustine (Florida).
• 2026 departures: January 29, February 5, February 12, February 19, February 26, March 5, March 12, November 21, November 28, December 5, December 12, December 19, December 26.
14-night East Coast Inland Passage cruises from Amelia Island (Florida) to Washington (DC). Visit Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head (South Carolina), Beaufort (South Carolina), Charleston (South Carolina), Wilmington (North Carolina), Morehead City (North Carolina), Kitty Hawk (North Carolina), Norfolk (Virginia) and St Michaels (Maryland).
• 2026 departures: March 28, April 17, May 13, May 22.
14-night Grand Florida Coast & Keys cruises from Amelia Island (Florida) to St Petersburg (Florida). Visit St Augustine (Florida), Port Canaveral (Florida), West Palm Beach (Florida), Key Biscayne (Florida), Key West (Florida), Marco Island (Florida) and Punta Gorda (Florida).
• 2026 departures: April 10, October 20, October 30, November 22.