The small ships of American Cruise Lines are ready to give you a unique experience out of the Jacksonville, Florida. The modern 100-passenger ships are small enough to travel calm inland waterways and dock at quaint ports.
Amenities on American Cruise Line include guest lecturers, musical entertainment, good food, complimentary cocktails, resort casual dress, comfortable lounges and large observation decks. Many of the spacious staterooms have private balconies.
7-night Southeast Sea Islands cruises to Charleston, South Carolina. Sail through the South on the calm Intracoastal Waterway. Ports of call include Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head Island (South Carolina) and Beaufort (South Carolina).
• 2026 departures: January 30, February 6, February 13, February 20, February 27, March 6, March 13, March 18, March 20, March 27, April 1, April 3, April 10, April 15, April 24, April 29, May 8, November 9, November 17, November 23, December 1, December 7, December 15, December 21, December 29.
7-night Great Rivers of Florida cruises. Round-trip from Jacksonville to Green Cove Springs (Florida), Jekyll Island (Georgia), Amelia Island (Florida), Tolomato River and St Augustine (Florida).
• 2026 departures: January 29, February 5, February 12, February 19, February 26, March 5, March 12, November 21, November 28, December 5, December 12, December 19, December 26.
14-night East Coast Inland Passage cruises from Amelia Island (Florida) to Washington (DC). Visit Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head (South Carolina), Beaufort (South Carolina), Charleston (South Carolina), Wilmington (North Carolina), Morehead City (North Carolina), Kitty Hawk (North Carolina), Norfolk (Virginia) and St Michaels (Maryland).
• 2026 departures: March 28, April 17, May 13, May 22.
14-night Grand Florida Coast & Keys cruises from Amelia Island (Florida) to St Petersburg (Florida). Visit St Augustine (Florida), Port Canaveral (Florida), West Palm Beach (Florida), Key Biscayne (Florida), Key West (Florida), Marco Island (Florida) and Punta Gorda (Florida).
• 2026 departures: April 10, October 20, October 30, November 22.
7-night Southeast Sea Islands cruises to Charleston, South Carolina. Sail through the South on the calm Intracoastal Waterway. Ports of call include Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head Island (South Carolina) and Beaufort (South Carolina).
• 2027 departures: January 27, January 29, February 3, February 10, February 12, February 17, February 24, February 26, March 3, March 10, March 12, March 17, March 19, March 26, March 31, April 2, April 9, April 14, April 16, April 23, April 30, May 7, May 21, June 4, August 6, August 20, September 3, September 17, October 1, October 15, October 29, November 8, November 12, November 15, November 22, November 26, November 29, December 6, December 10, December 13, December 20, December 26.
7-night Great Rivers of Florida cruises. Round-trip from Jacksonville to Green Cove Springs (Florida), Jekyll Island (Georgia), Amelia Island (Florida), Tolomato River and St Augustine (Florida).
• 2027 departures: January 29, February 5, February 12, February 19, February 26, March 5, March 12, May 14, November 9, November 22, November 29, December 6, December 12, December 19, December 26.
14-night East Coast Inland Passage cruises from Amelia Island (Florida) to Washington (DC). Visit Jekyll Island (Georgia), St Simons Island (Georgia), Savannah (Georgia), Hilton Head (South Carolina), Beaufort (South Carolina), Charleston (South Carolina), Wilmington (North Carolina), Morehead City (North Carolina), Kitty Hawk (North Carolina), Norfolk (Virginia) and St Michaels (Maryland).
• 2027 departures: March 24, April 28, May 21, June 18.
14-night Grand Florida Coast & Keys cruises from Amelia Island (Florida) to St Petersburg (Florida). Visit Green Cove Springs (Florida), St Augustine (Florida), Cape Canaveral (Florida), West Palm Beach (Florida), Key Biscayne (Florida), Key West (Florida), Marco Island (Florida) and Punta Gorda (Florida).
• 2027 departures: November 2, November 7, November 12.