November 18, 2017: 7-night Great Rivers of Florida cruise on American Cruise Lines. Round-trip from Jacksonville on the St John's and Tolomato rivers to Green Cove Springs, St Augustine, and Amelia Island.
November 18, 2017: 7-night Historic South & Golden Isles cruise on American Cruise Lines. One-way to Charleston, South Carolina. Cruise on the Intracoastal Waterway to Jekyll Island (Georgia), Sapelo Island (Georgia), Savannah (Georgia), Hilton Head (South Carolina), and Beaufort (South Carolina).
November 23, 2017: Carnival Cruise Line 4-day Bahamas Thanksgiving cruise that departs on Thanksgiving Day. Round-trip from Jacksonville to Nassau and Freeport in the Bahamas.
You may also be interested in Thanksgiving cruises from Charleston SC. Also see our complete calendar of cruises leaving from Jacksonville FL.